2YCS
Crystal structure of checkpoint kinase 2 in complex with PV788
Summary for 2YCS
Entry DOI | 10.2210/pdb2ycs/pdb |
Related | 1GXC 2CN5 2CN8 2W0J 2W7X 2WTC 2WTD 2WTI 2WTJ 2XBJ 2XM8 2XM9 2YCF 2YCQ 2YCR |
Descriptor | SERINE/THREONINE-PROTEIN KINASE CHK2, N-{4-[(1E)-N-CARBAMIMIDOYLETHANEHYDRAZONOYL]PHENYL}-1H-INDOLE-3-CARBOXAMIDE, NITRATE ION, ... (4 entities in total) |
Functional Keywords | transferase, anticancer drug design |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Isoform 2: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 9: Nucleus. Isoform 12: Nucleus. Nucleus, PML body: O96017 |
Total number of polymer chains | 1 |
Total formula weight | 36958.62 |
Authors | Lountos, G.T.,Jobson, A.G.,Tropea, J.E.,Self, C.R.,Pommier, Y.,Shoemaker, R.H.,Zhang, G.,Waugh, D.S. (deposition date: 2011-03-16, release date: 2011-11-16, Last modification date: 2023-12-20) |
Primary citation | Lountos, G.T.,Jobson, A.G.,Tropea, J.E.,Self, C.R.,Zhang, G.,Pommier, Y.,Shoemaker, R.H.,Waugh, D.S. Structural Characterization of Inhibitor Complexes with Checkpoint Kinase 2 (Chk2), a Drug Target for Cancer Therapy. J.Struct.Biol., 176:292-, 2011 Cited by PubMed: 21963792DOI: 10.1016/J.JSB.2011.09.008 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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