2X11
Crystal structure of the complete EphA2 ectodomain in complex with ephrin A5 receptor binding domain
Summary for 2X11
Entry DOI | 10.2210/pdb2x11/pdb |
Related | 1MQB 2X10 |
Descriptor | EPHRIN TYPE-A RECEPTOR 2, EPHRIN-A5 (2 entities in total) |
Functional Keywords | receptor-signaling protein complex, developmental protein, signaling platform, kinase, transferase, neurogenesis, receptor, cataract, apoptosis, erythropoietin-producing hepatocellular carcinoma, angiogenesis, signaling protein, receptor/signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 80261.54 |
Authors | Seiradake, E.,Harlos, K.,Sutton, G.,Aricescu, A.R.,Jones, E.Y. (deposition date: 2009-12-21, release date: 2010-03-16, Last modification date: 2023-12-20) |
Primary citation | Seiradake, E.,Harlos, K.,Sutton, G.,Aricescu, A.R.,Jones, E.Y. An Extracellular Steric Seeding Mechanism for Eph-Ephrin Signalling Platform Assembly Nat.Struct.Mol.Biol., 17:398-, 2010 Cited by PubMed: 20228801DOI: 10.1038/NSMB.1782 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (4.83 Å) |
Structure validation
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