2WV8
Complex of human dihydroorotate dehydrogenase with the inhibitor 221290
Summary for 2WV8
Entry DOI | 10.2210/pdb2wv8/pdb |
Related | 1D3G 1D3H 2B0M 2BXV |
Descriptor | DIHYDROOROTATE DEHYDROGENASE, MITOCHONDRIAL, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (8 entities in total) |
Functional Keywords | flavoprotein, transmembrane, mitochondrion inner membrane, oxidoreductase, transit peptide, enzyme inhibition, pyrimidine biosynthesis, structure-based drug design, inflamation |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Mitochondrion inner membrane ; Single-pass membrane protein : Q02127 |
Total number of polymer chains | 1 |
Total formula weight | 40954.53 |
Authors | Walse, B.,Svensson, B.,Fritzson, I.,Dahlberg, L.,Wellmar, U.,Al-Karadaghi, S. (deposition date: 2009-10-15, release date: 2010-08-25, Last modification date: 2024-05-08) |
Primary citation | Fritzson, I.,Svensson, B.,Al-Karadaghi, S.,Walse, B.,Wellmar, U.,Nilsson, U.J.,Da Graca Thrige, D.,Jonsson, S. Inhibition of Human Dhodh by 4-Hydroxycoumarins, Fenamic Acids, and N-(Alkylcarbonyl)Anthranilic Acids Identified by Structure-Guided Fragment Selection. Chemmedchem, 5:608-, 2010 Cited by PubMed: 20183850DOI: 10.1002/CMDC.200900454 PDB entries with the same primary citation |
Experimental method |
Structure validation
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