2WJZ

Crystal structure of (HisH) K181A Y138A mutant of imidazoleglycerolphosphate synthase (HisH HisF) which displays constitutive glutaminase activity

Summary for 2WJZ

Entry DOI	10.2210/pdb2wjz/pdb
Related	1GPW 1K9V 1KXJ 1THF 1VH7 2A0N 2W6R
Descriptor	IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISF, IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISH, PHOSPHATE ION, ... (4 entities in total)
Functional Keywords	lyase-transferase complex, amino-acid biosynthesis, ammonia channel, histidine biosynthesis, cyclase, glutaminase, lyase/transferase
Biological source	THERMOTOGA MARITIMA More
Cellular location	Cytoplasm: Q9X0C6 Q9X0C8
Total number of polymer chains	6
Total formula weight	152487.63
Authors	Vega, M.C.,List, F.,Razeto, A.,Haeger, M.C.,Babinger, K.,Kuper, J.,Sterner, R.,Wilmanns, M. (deposition date: 2009-06-02, release date: 2010-08-25, Last modification date: 2023-12-13)
Primary citation	List, F.,Vega, M.C.,Razeto, A.,Hager, M.C.,Sterner, R.,Wilmanns, M. Catalysis Uncoupling in a Glutamine Amidotransferase Bienzyme by Unblocking the Glutaminase Active Site. Chem.Biol., 19:1589-, 2012 Cited by PubMed: 23261602 DOI: 10.1016/J.CHEMBIOL.2012.10.012 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.601 Å)

Structure validation