2VD0
Complex structure of prostaglandin D2 synthase at 2.2A.
Summary for 2VD0
Entry DOI | 10.2210/pdb2vd0/pdb |
Related | 1IYH 1IYI 1V40 2VCQ 2VCW 2VCX 2VCZ |
Descriptor | GLUTATHIONE-REQUIRING PROSTAGLANDIN D SYNTHASE, GLUTATHIONE, 2-{[(2E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino}benzoic acid, ... (5 entities in total) |
Functional Keywords | prostaglandin biosynthesis, fatty acid biosynthesis, prostaglandin d2 synthase, pgds, asthma, cytoplasm, isomerase, lipid synthesis |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm: O60760 |
Total number of polymer chains | 4 |
Total formula weight | 94824.71 |
Authors | Hohwy, M.,Spadola, L.,Lundquist, B.,von Wachenfeldt, K.,Persdotter, S.,Hawtin, P.,Dahmen, J.,Groth-Clausen, I.,Folmer, R.H.A.,Edman, K. (deposition date: 2007-09-28, release date: 2008-04-15, Last modification date: 2023-12-13) |
Primary citation | Hohwy, M.,Spadola, L.,Lundquist, B.,Hawtin, P.,Dahmen, J.,Groth-Clausen, I.,Nilsson, E.,Persdotter, S.,Von Wachenfeldt, K.,Folmer, R.H.A.,Edman, K. Novel Prostaglandin D Synthase Inhibitors Generated by Fragment-Based Drug Design. J.Med.Chem., 51:2178-, 2008 Cited by PubMed: 18341273DOI: 10.1021/JM701509K PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
Download full validation report