2RL9

Crystal Structure cation-dependent mannose 6-phosphate receptor at pH 6.5 bound to trimannoside

Summary for 2RL9

Entry DOI	10.2210/pdb2rl9/pdb
Related	2RL6 2RL7 2RL8 2RLB
Descriptor	Cation-dependent mannose-6-phosphate receptor, 6-O-phosphono-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	p-type lectin, receptor, mannose 6-phosphate, lectin, glycoprotein, lysosome, membrane, transmembrane, transport, protein transport, sugar binding protein
Biological source	Bos taurus (cattle)
Cellular location	Lysosome membrane ; Single-pass type I membrane protein : P11456
Total number of polymer chains	2
Total formula weight	36608.29
Authors	Olson, L.J.,Hindsgaul, O.,Dahms, N.M.,Kim, J.-J.P. (deposition date: 2007-10-18, release date: 2008-02-12, Last modification date: 2021-10-20)
Primary citation	Olson, L.J.,Hindsgaul, O.,Dahms, N.M.,Kim, J.J. Structural insights into the mechanism of pH-dependent ligand binding and release by the cation-dependent mannose 6-phosphate receptor. J.Biol.Chem., 283:10124-10134, 2008 Cited by PubMed: 18272523 DOI: 10.1074/jbc.M708994200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation