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2RGU

Crystal structure of complex of human DPP4 and inhibitor

Summary for 2RGU
Entry DOI10.2210/pdb2rgu/pdb
DescriptorDipeptidyl peptidase 4, 2-acetamido-2-deoxy-beta-D-glucopyranose, 8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-3,7-dihydro-1H-purine-2,6-d ione, ... (4 entities in total)
Functional Keywordspeptidase, inhibitor, aminopeptidase, glycoprotein, hydrolase, membrane, protease, secreted, serine protease, signal-anchor, transmembrane
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total formula weight173297.76
Authors
Nar, H.,Himmelsbach, F.,Eckhardt, M. (deposition date: 2007-10-05, release date: 2007-11-06, Last modification date: 2020-07-29)
Primary citationEckhardt, M.,Langkopf, E.,Mark, M.,Tadayyon, M.,Thomas, L.,Nar, H.,Pfrengle, W.,Guth, B.,Lotz, R.,Sieger, P.,Fuchs, H.,Himmelsbach, F.
8-(3-(R)-Aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a Highly Potent, Selective, Long-Acting, and Orally Bioavailable DPP-4 Inhibitor for the Treatment of Type 2 Diabetes.
J.Med.Chem., 50:6450-6453, 2007
Cited by
PubMed: 18052023
DOI: 10.1021/jm701280z
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.6 Å)
Structure validation

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