2RGU

Crystal structure of complex of human DPP4 and inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Dipeptidyl peptidase 4	polymer	734	85291.5	2	UniProt (P27487) Pfam (PF00930) Pfam (PF00326)	Homo sapiens (human)	Dipeptidyl peptidase IV, DPP IV, T-cell activation antigen CD26, TP103, Adenosine deaminase complexing protein 2, ADABP (Contains: Dipeptidyl peptidase 4 membrane form, Dipeptidyl peptidase 4 soluble form)
2	C, D, E, F, H... (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	8	Chemie (NAG)
3	G, L (A, B)	8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-3,7-dihydro-1H-purine-2,6-d ione	non-polymer		472.5	2	Chemie (356)
4	M, N (A, B)	water	water		18.0	207	Chemie (HOH)

Sequence modifications

A, B: 39 - 766 (UniProt: P27487)

PDB	External Database	Details
His 767	-	expression tag
His 768	-	expression tag
His 769	-	expression tag
His 770	-	expression tag
His 771	-	expression tag
His 772	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	170583.0
Non-Polymers*	Number of molecules	10
	Total formula weight	2714.7
All*	Total formula weight	173297.8

*Water molecules are not included.