2RGU
Crystal structure of complex of human DPP4 and inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Dipeptidyl peptidase 4 | polymer | 734 | 85291.5 | 2 | UniProt (P27487) Pfam (PF00930) Pfam (PF00326) In PDB | Homo sapiens (human) | Dipeptidyl peptidase IV, DPP IV, T-cell activation antigen CD26, TP103, Adenosine deaminase complexing protein 2, ADABP (Contains: Dipeptidyl peptidase 4 membrane form, Dipeptidyl peptidase 4 soluble form) |
2 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 8 | Chemie (NAG) | |||
3 | A, B | 8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-3,7-dihydro-1H-purine-2,6-d ione | non-polymer | 472.5 | 2 | Chemie (356) | |||
4 | water | water | 18.0 | 207 | Chemie (HOH) |
Sequence modifications
A, B: 39 - 766 (UniProt: P27487)
PDB | External Database | Details |
---|---|---|
His 767 | - | expression tag |
His 768 | - | expression tag |
His 769 | - | expression tag |
His 770 | - | expression tag |
His 771 | - | expression tag |
His 772 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 170583.0 | |
Non-Polymers* | Number of molecules | 10 |
Total formula weight | 2714.7 | |
All* | Total formula weight | 173297.8 |