2QZR

tRNA-Guanine Transglycosylase(TGT) in Complex with 6-amino-2-[(1-naphthylmethyl)amino]-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one

Summary for 2QZR

Entry DOI	10.2210/pdb2qzr/pdb
Related	1P0E 1PUD 1Y5V 1Y5W 1Y5X 2BBF
Descriptor	Queuine tRNA-ribosyltransferase, ZINC ION, 6-amino-2-[(1-naphthylmethyl)amino]-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one, ... (5 entities in total)
Functional Keywords	transferase, glycosyltransferase, metal-binding, queuosine biosynthesis, trna processing
Biological source	Zymomonas mobilis
Total number of polymer chains	1
Total formula weight	43400.49
Authors	Hoertner, S.R.,Ritschel, T.,Stengl, B.,Kramer, C.,Schweizer, W.B.,Wagner, B.,Kansy, M.,Klebe, G.,Diederich, F. (deposition date: 2007-08-17, release date: 2007-09-11, Last modification date: 2023-08-30)
Primary citation	Hortner, S.R.,Ritschel, T.,Stengl, B.,Kramer, C.,Schweizer, W.B.,Wagner, B.,Kansy, M.,Klebe, G.,Diederich, F. Potent Inhibitors of tRNA-Guanine Transglycosylase, an Enzyme Linked to the Pathogenicity of the Shigella Bacterium: Charge-Assisted Hydrogen Bonding. Angew.Chem.Int.Ed.Engl., 46:8266-8269, 2007 Cited by PubMed: 17902085 DOI: 10.1002/anie.200702961 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation