2QX1

Crystal structure of the complex between mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III (FABH) and decyl-COA disulfide

Summary for 2QX1

Entry DOI	10.2210/pdb2qx1/pdb
Related	1HNJ 1HNK 1HZP 1U6E 1U6S
Descriptor	Beta-ketoacyl-ACP synthase III, COENZYME A, DECANE-1-THIOL, ... (4 entities in total)
Functional Keywords	fatty acid biosynthesis, myobacterium tuberculosis, structural basis for substrate specificity, enzyme inhibitor complex, mechanism based inhibitor, acyltransferase, lipid synthesis, multifunctional enzyme, transferase
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	2
Total formula weight	70923.01
Authors	Sachdeva, S.,Musayev, F.,Alhamadsheh, M.,Scarsdale, J.N.,Wright, H.T.,Reynolds, K.A. (deposition date: 2007-08-10, release date: 2008-03-18, Last modification date: 2023-08-30)
Primary citation	Sachdeva, S.,Musayev, F.,Alhamadsheh, M.M.,Neel Scarsdale, J.,Tonie Wright, H.,Reynolds, K.A. Probing reactivity and substrate specificity of both subunits of the dimeric Mycobacterium tuberculosis FabH using alkyl-CoA disulfide inhibitors and acyl-CoA substrates Bioorg.Chem., 36:85-90, 2008 Cited by PubMed: 18096200 DOI: 10.1016/j.bioorg.2007.11.001 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation