2QJR

dipepdyl peptidase IV in complex with inhibitor PZF

Summary for 2QJR

• Entry DOI: 10.2210/pdb2qjr/pdb
• Descriptor: Dipeptidyl peptidase 4 membrane form, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-alpha-L-gulopyranuronic acid-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: protein-inhibitor complex, aminopeptidase, glycoprotein, hydrolase, membrane, protease, secreted, serine protease, signal-anchor, transmembrane
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 177621.84

Authors

Shenping, L. (deposition date: 2007-07-09, release date: 2008-07-29, Last modification date: 2024-11-06)

Primary citation

Wright, S.W.,Ammirati, M.J.,Andrews, K.M.,Brodeur, A.M.,Danley, D.E.,Doran, S.D.,Lillquist, J.S.,Liu, S.,McClure, L.D.,McPherson, R.K.,Olson, T.V.,Orena, S.J.,Parker, J.C.,Rocke, B.N.,Soeller, W.C.,Soglia, C.B.,Treadway, J.L.,Vanvolkenburg, M.A.,Zhao, Z.,Cox, E.D.
(3R,4S)-4-(2,4,5-Trifluorophenyl)-pyrrolidin-3-ylamine inhibitors of dipeptidyl peptidase IV: synthesis, in vitro, in vivo, and X-ray crystallographic characterization.
Bioorg.Med.Chem.Lett., 17:5638-5642, 2007

PubMed Abstract: A series of pyrrolidine based inhibitors of dipeptidyl peptidase IV were developed from a high throughput screening hit for the treatment of type 2 diabetes. Potency, selectivity, and pharmacokinetic properties were optimized resulting in the identification of a pre-clinical candidate for further profiling.

PubMed: 17822893
DOI: 10.1016/j.bmcl.2007.07.081

Experimental method

X-RAY DIFFRACTION (2.2 Å)