2QJR

dipepdyl peptidase IV in complex with inhibitor PZF

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Dipeptidyl peptidase 4 membrane form	polymer	748	86648.9	2	UniProt (P27487) Pfam (PF00930) Pfam (PF00326) In PDB	Homo sapiens (human)	Dipeptidyl peptidase IV membrane form
2	C, E, F, G, H	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	5	In PDB GlyTouCan (G42666HT)
3	D	alpha-D-mannopyranose-(1-3)-alpha-L-gulopyranuronic acid-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		762.7	1	In PDB
4	A, B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
5	A, B	(3R,4S)-1-[6-(6-METHOXYPYRIDIN-3-YL)PYRIMIDIN-4-YL]-4-(2,4,5-TRIFLUOROPHENYL)PYRROLIDIN-3-AMINE	non-polymer		401.4	2	Chemie (PZF)
6	A	alpha-L-gulopyranuronic acid	non-polymer		194.1	1	Chemie (LGU)
7		water	water		18.0	331	Chemie (HOH)

Sequence modifications

A, B: 31 - 766 (UniProt: P27487)

PDB	External Database	Details
Leu 767	-	expression tag
Val 768	-	expression tag
Pro 769	-	expression tag
Arg 770	-	expression tag
Gly 771	-	expression tag
Ser 772	-	expression tag
His 773	-	expression tag
His 774	-	expression tag
His 775	-	expression tag
His 776	-	expression tag
His 777	-	expression tag
His 778	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	173297.8
Branched	Number of molecules	6
	Total formula weight	2884.7
Non-Polymers*	Number of molecules	5
	Total formula weight	1439.3
All*	Total formula weight	177621.8

*Water molecules are not included.