2Q20

Structure of the germline Vk1 O18/O8 light chain variable domain homodimer

Summary for 2Q20

• Entry DOI: 10.2210/pdb2q20/pdb
• Related: 2Q1E
• Descriptor: Vk1 O18/O8 germline light chain variable domain (2 entities in total)
• Functional Keywords: vk1, germline, al, light chain amyloidosis, amyloid, immunoglobulin, light chain, light chain variable domain, protein fibril
• Biological source: Homo sapiens (human)
• Cellular location: Secreted : P01594
• Total number of polymer chains: 2
• Total formula weight: 23942.24

Authors

Thompson, J.R.,Ramirez-Alvarado, M.,Baden, E.M. (deposition date: 2007-05-25, release date: 2008-04-08, Last modification date: 2023-08-30)

• Primary citation: Baden, E.M.,Owen, B.A.,Peterson, F.C.,Volkman, B.F.,Ramirez-Alvarado, M.,Thompson, J.R.; Altered dimer interface decreases stability in an amyloidogenic protein.; J.Biol.Chem., 283:15853-15860, 2008; PubMed: 18400753; DOI: 10.1074/jbc.M705347200

Experimental method

X-RAY DIFFRACTION (1.3 Å)