2PVY
Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K659N Mutation Responsible for an Unclassified Craniosynostosis Syndrome.
Summary for 2PVY
Entry DOI | 10.2210/pdb2pvy/pdb |
Related | 2PSQ 2PVF 2PWL 2PY3 2PZ5 2PZP 2PZR 2Q0B |
Descriptor | Fibroblast growth factor receptor 2, SULFATE ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (4 entities in total) |
Functional Keywords | kinase domain fold consisting of n- and c-lobes, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 3: Cell membrane; Single-pass type I membrane protein. Isoform 14: Secreted. Isoform 19: Secreted: P21802 |
Total number of polymer chains | 4 |
Total formula weight | 150787.10 |
Authors | Chen, H.,Mohammadi, M. (deposition date: 2007-05-10, release date: 2007-09-25, Last modification date: 2023-08-30) |
Primary citation | Chen, H.,Ma, J.,Li, W.,Eliseenkova, A.V.,Xu, C.,Neubert, T.A.,Miller, W.T.,Mohammadi, M. A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases. Mol.Cell, 27:717-730, 2007 Cited by PubMed: 17803937DOI: 10.1016/j.molcel.2007.06.028 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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