2PUQ

Crystal structure of active site inhibited coagulation factor VIIA in complex with soluble tissue factor

Replaces:  2PMM

Summary for 2PUQ

• Entry DOI: 10.2210/pdb2puq/pdb
• Related PRD ID: PRD_000285
• Descriptor: Coagulation factor VII, Tissue factor, TRP-TYR-THR-ARG CHLOROMETHYLKETONE INHIBITOR, ... (8 entities in total)
• Functional Keywords: active site inhibitor, blood clotting, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 62576.05

Authors

Bjelke, J.R.,Rasmussen, H.B. (deposition date: 2007-05-09, release date: 2007-05-22, Last modification date: 2023-08-30)

• Primary citation: Larsen, K.S.,Ostergaard, H.,Bjelke, J.R.,Olsen, O.H.,Rasmussen, H.B.,Christensen, L.,Kragelund, B.B.,Stennicke, H.R.; Engineering the substrate and inhibitor specificities of human coagulation Factor VIIa; Biochem.J., 405:429-438, 2007; PubMed: 17456045; DOI: 10.1042/BJ20061901

Experimental method

X-RAY DIFFRACTION (2.05 Å)