2OYE
Indomethacin-(R)-alpha-ethyl-ethanolamide bound to Cyclooxygenase-1
Summary for 2OYE
Entry DOI | 10.2210/pdb2oye/pdb |
Related | 1CQE 1EQE 1PGF 1PGG |
Descriptor | Prostaglandin G/H synthase 1, 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total) |
Functional Keywords | cox, pghs, indomethacin, nsaid, heme, oxidoreductase |
Biological source | Ovis aries (sheep) |
Total number of polymer chains | 1 |
Total formula weight | 72267.83 |
Authors | Harman, C.A.,Garavito, R.M. (deposition date: 2007-02-21, release date: 2007-07-24, Last modification date: 2020-07-29) |
Primary citation | Harman, C.A.,Turman, M.V.,Kozak, K.R.,Marnett, L.J.,Smith, W.L.,Garavito, R.M. Structural basis of enantioselective inhibition of cyclooxygenase-1 by S-alpha-substituted indomethacin ethanolamides. J.Biol.Chem., 282:28096-28105, 2007 Cited by PubMed: 17656360DOI: 10.1074/jbc.M701335200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.85 Å) |
Structure validation
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