2OP9

Substrate Specificity Profiling and Identification of a New Class of Inhibitor for the Major Protease of the SARS Coronavirus

Summary for 2OP9

• Entry DOI: 10.2210/pdb2op9/pdb
• Descriptor: Replicase polyprotein 1ab (pp1ab, ORF1AB) 3C-like proteinase (3CL-PRO, 3CLp), NALPHA-[(BENZYLOXY)CARBONYL]-N-[(1R)-4-HYDROXY-1-METHYL-2-OXOBUTYL]-L-PHENYLALANINAMIDE (3 entities in total)
• Functional Keywords: sars, 3clpro, proteinase, protease, hydrolase
• Biological source: SARS coronavirus
• Total number of polymer chains: 2
• Total formula weight: 67627.16

Authors

Craik, C.S.,Goetz, D.H. (deposition date: 2007-01-27, release date: 2007-07-17, Last modification date: 2023-12-27)

• Primary citation: Goetz, D.H.,Choe, Y.,Hansell, E.,Chen, Y.T.,McDowell, M.,Jonsson, C.B.,Roush, W.R.,McKerrow, J.,Craik, C.S.; Substrate Specificity Profiling and Identification of a New Class of Inhibitor for the Major Protease of the SARS Coronavirus.; Biochemistry, 46:8744-8752, 2007; PubMed: 17605471; DOI: 10.1021/bi0621415

Experimental method

X-RAY DIFFRACTION (1.8 Å)