2OIQ
Crystal Structure of chicken c-Src kinase domain in complex with the cancer drug imatinib.
Summary for 2OIQ
Entry DOI | 10.2210/pdb2oiq/pdb |
Descriptor | Proto-oncogene tyrosine-protein kinase Src, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, GLYCEROL, ... (4 entities in total) |
Functional Keywords | src, kinase, imatinib, inactive, transferase |
Biological source | Gallus gallus (chicken) |
Total number of polymer chains | 2 |
Total formula weight | 66131.08 |
Authors | Seeliger, M.A.,Nagar, B.,Frank, F.,Cao, X.,Henderson, M.N.,Kuriyan, J. (deposition date: 2007-01-11, release date: 2007-03-20, Last modification date: 2023-08-30) |
Primary citation | Seeliger, M.A.,Nagar, B.,Frank, F.,Cao, X.,Henderson, M.N.,Kuriyan, J. c-Src Binds to the Cancer Drug Imatinib with an Inactive Abl/c-Kit Conformation and a Distributed Thermodynamic Penalty. Structure, 15:299-311, 2007 Cited by PubMed: 17355866DOI: 10.1016/j.str.2007.01.015 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.07 Å) |
Structure validation
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