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2OHR

X-ray crystal structure of beta secretase complexed with compound 6a

Summary for 2OHR
Entry DOI10.2210/pdb2ohr/pdb
Related2OF0 2OHK 2OHL 2OHM 2OHN 2OHP 2OHQ 2OHS 2OHT 2OHU
DescriptorBeta-secretase 1, IODIDE ION, DIMETHYL SULFOXIDE, ... (6 entities in total)
Functional Keywordsalzheimer's disease, aspartic protease, aspartyl protease, base, beta-secretase, glycoprotein, hydrolase, memapsin 2, transmembrane, zymogen
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type I membrane protein: P56817
Total number of polymer chains1
Total formula weight45541.77
Authors
Patel, S. (deposition date: 2007-01-10, release date: 2007-03-13, Last modification date: 2023-08-30)
Primary citationCongreve, M.,Aharony, D.,Albert, J.,Callaghan, O.,Campbell, J.,Carr, R.A.,Chessari, G.,Cowan, S.,Edwards, P.D.,Frederickson, M.,McMenamin, R.,Murray, C.W.,Patel, S.,Wallis, N.
Application of fragment screening by X-ray crystallography to the discovery of aminopyridines as inhibitors of beta-secretase.
J.Med.Chem., 50:1124-1132, 2007
Cited by
PubMed: 17315857
DOI: 10.1021/jm061197u
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.25 Å)
Structure validation

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