2OHM

X-ray crystal structure of beta secretase complexed with N~3~-benzylpyridine-2,3-diamine

Summary for 2OHM

Entry DOI	10.2210/pdb2ohm/pdb
Related	2OF0 2OHK 2OHL 2OHN 2OHP 2OHQ 2OHR 2OHS 2OHT 2OHU
Descriptor	Beta-secretase 1, IODIDE ION, DIMETHYL SULFOXIDE, ... (5 entities in total)
Functional Keywords	alternative splicing, alzheimer's disease, aspartic protease, aspartyl protease, base, beta-secretase, glycoprotein, hydrolase, memapsin 2, transmembrane, zymogen
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein: P56817
Total number of polymer chains	1
Total formula weight	45372.59
Authors	Patel, S. (deposition date: 2007-01-10, release date: 2007-03-13, Last modification date: 2023-08-30)
Primary citation	Murray, C.W.,Callaghan, O.,Chessari, G.,Cleasby, A.,Congreve, M.,Frederickson, M.,Hartshorn, M.J.,McMenamin, R.,Patel, S.,Wallis, N. Application of fragment screening by X-ray crystallography to beta-Secretase. J.Med.Chem., 50:1116-1123, 2007 Cited by PubMed: 17315856 DOI: 10.1021/jm0611962 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation