2OH0

Crystal structure of Protein Kinase A in complex with Pyridine-Pyrazolopyridine Based Inhibitors

Summary for 2OH0

• Entry DOI: 10.2210/pdb2oh0/pdb
• Related: 2F7Z
• Descriptor: cAMP-dependent protein kinase, alpha-catalytic subunit, Inhibitory peptide, (2S)-1-{[5-(1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}-3-[(7AS)-7AH-INDOL-3-YL]PROPAN-2-AMINE (3 entities in total)
• Functional Keywords: protein kinase a, akt, transferase
• Biological source: Bos taurus (cattle)
• Cellular location: Cytoplasm: P00517
• Total number of polymer chains: 2
• Total formula weight: 43287.51

Authors

Stoll, V.S. (deposition date: 2007-01-09, release date: 2007-03-20, Last modification date: 2023-12-27)

• Primary citation: Zhu, G.D.,Gong, J.,Gandhi, V.B.,Woods, K.,Luo, Y.,Liu, X.,Guan, R.,Klinghofer, V.,Johnson, E.F.,Stoll, V.S.,Mamo, M.,Li, Q.,Rosenberg, S.H.,Giranda, V.L.; Design and synthesis of pyridine-pyrazolopyridine-based inhibitors of protein kinase B/Akt.; Bioorg.Med.Chem., 15:2441-2452, 2007; PubMed: 17258463; DOI: 10.1016/j.bmc.2007.01.010

Experimental method

X-RAY DIFFRACTION (2.2 Å)