2NQI

Calpain 1 proteolytic core inactivated by WR13(R,R), an epoxysuccinyl-type inhibitor.

Summary for 2NQI

Entry DOI	10.2210/pdb2nqi/pdb
Related	1KXR 1TL9 1TLO 2G8E 2G8J 2NQG
Descriptor	Calpain-1 catalytic subunit, CALCIUM ION, N~2~-[(2S)-2-{[(2R)-4-ETHOXY-2-HYDROXY-4-OXOBUTANOYL]AMINO}PENT-4-ENOYL]-L-ARGINYL-L-TRYPTOPHANAMIDE, ... (4 entities in total)
Functional Keywords	epoxide, epoxysuccinyl, protease, peptidase, proteinase, inactivator, inhibitor, hydrolase
Biological source	Rattus norvegicus (Norway rat)
Cellular location	Cytoplasm : P97571
Total number of polymer chains	1
Total formula weight	39485.37
Authors	Cuerrier, D.,Davies, P.L.,Campbell, R.L.,Moldoveanu, T. (deposition date: 2006-10-31, release date: 2007-01-09, Last modification date: 2023-08-30)
Primary citation	Cuerrier, D.,Moldoveanu, T.,Campbell, R.L.,Kelly, J.,Yoruk, B.,Verhelst, S.H.L.,Greenbaum, D.,Bogyo, M.,Davies, P.L. Development of Calpain-specific Inactivators by Screening of Positional Scanning Epoxide Libraries J.Biol.Chem., 282:9600-9611, 2007 Cited by PubMed: 17218315 DOI: 10.1074/jbc.M610372200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.04 Å)

Structure validation