2NPU
The solution structure of the rapamycin-binding domain of mTOR (FRB)
Summary for 2NPU
Entry DOI | 10.2210/pdb2npu/pdb |
NMR Information | BMRB: 6760 |
Descriptor | FKBP12-rapamycin complex-associated protein (1 entity in total) |
Functional Keywords | four-helix bundle, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 15361.41 |
Authors | Veverka, V.,Crabbe, T.,Bird, I.,Lennie, G.,Muskett, F.W.,Taylor, R.J.,Carr, M.D. (deposition date: 2006-10-30, release date: 2007-09-18, Last modification date: 2024-05-15) |
Primary citation | Veverka, V.,Crabbe, T.,Bird, I.,Lennie, G.,Muskett, F.W.,Taylor, R.J.,Carr, M.D. Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR. Oncogene, 27:585-595, 2008 Cited by PubMed: 17684489DOI: 10.1038/sj.onc.1210693 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
Download full validation report