2NNX

Crystal Structure of the H46R, H48Q double mutant of human [Cu-Zn] Superoxide Dismutase

Summary for 2NNX

Entry DOI	10.2210/pdb2nnx/pdb
Descriptor	SUPEROXIDE DISMUTASE [CU-ZN], ZINC ION, SULFATE ION, ... (4 entities in total)
Functional Keywords	oxidoreductase; human; cu-zn superoxide dismutase; superoxide acceptor; familial amyotrophic lateral sclerosis mutant, oxidoreductase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	64069.85
Authors	Schuermann, J.P.,Hart, P.J. (deposition date: 2006-10-24, release date: 2006-11-07, Last modification date: 2023-08-30)
Primary citation	Wang, J.,Caruano-Yzermans, A.,Rodriguez, A.,Scheurmann, J.P.,Slunt, H.H.,Cao, X.,Gitlin, J.,Hart, P.J.,Borchelt, D.R. Disease-associated mutations at copper ligand histidine residues of superoxide dismutase 1 diminish the binding of copper and compromise dimer stability J.Biol.Chem., 282:345-352, 2007 Cited by PubMed: 17092942 DOI: 10.1074/jbc.M604503200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation