2MV7
Solution NMR structure of DOT1L in complex with AF9 (DOT1L-AF9)
Summary for 2MV7
Entry DOI | 10.2210/pdb2mv7/pdb |
Related | 2LM0 |
NMR Information | BMRB: 19516 |
Descriptor | Protein AF-9, Histone-lysine N-methyltransferase, H3 lysine-79 specific (2 entities in total) |
Functional Keywords | mixed lineage leukemia, leukemia, protein binding-transferase complex, protein binding/transferase |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus : P42568 Q8TEK3 |
Total number of polymer chains | 2 |
Total formula weight | 10814.33 |
Authors | Kuntimaddi, A.,Bushweller, J.H. (deposition date: 2014-09-24, release date: 2015-04-22, Last modification date: 2024-05-15) |
Primary citation | Kuntimaddi, A.,Achille, N.J.,Thorpe, J.,Lokken, A.A.,Singh, R.,Hemenway, C.S.,Adli, M.,Zeleznik-Le, N.J.,Bushweller, J.H. Degree of Recruitment of DOT1L to MLL-AF9 Defines Level of H3K79 Di- and Tri-methylation on Target Genes and Transformation Potential. Cell Rep, 11:808-820, 2015 Cited by PubMed: 25921540DOI: 10.1016/j.celrep.2015.04.004 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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