2MUV
NOE-based model of the influenza A virus M2 (19-49) bound to drug 11
Summary for 2MUV
Entry DOI | 10.2210/pdb2muv/pdb |
Related | 2MUW |
NMR Information | BMRB: 25233 |
Descriptor | Matrix protein 2, (3s,5s,7s)-N-[(5-bromothiophen-2-yl)methyl]tricyclo[3.3.1.1~3,7~]decan-1-aminium (2 entities in total) |
Functional Keywords | drug design, m2, viral protein |
Biological source | Influenza A virus |
Cellular location | Virion membrane : B0LX40 |
Total number of polymer chains | 4 |
Total formula weight | 14315.77 |
Authors | Wu, Y.,Wang, J.,DeGrado, W. (deposition date: 2014-09-18, release date: 2014-12-24, Last modification date: 2024-05-15) |
Primary citation | Wu, Y.,Canturk, B.,Jo, H.,Ma, C.,Gianti, E.,Klein, M.L.,Pinto, L.H.,Lamb, R.A.,Fiorin, G.,Wang, J.,DeGrado, W.F. Flipping in the Pore: Discovery of Dual Inhibitors That Bind in Different Orientations to the Wild-Type versus the Amantadine-Resistant S31N Mutant of the Influenza A Virus M2 Proton Channel. J.Am.Chem.Soc., 136:17987-17995, 2014 Cited by PubMed: 25470189DOI: 10.1021/ja508461m PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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