2MU8

Residues belonging the n-terminal region derived of merozoite surface protein-2 of plasmodium falciparum

Summary for 2MU8

Entry DOI	10.2210/pdb2mu8/pdb
Related	2MU7
NMR Information	BMRB: 25202
Descriptor	MSP-2 peptide (1 entity in total)
Functional Keywords	merozoite surface protein 2, classic beta-turn, cell invasion
Biological source	Plasmodium falciparum
Total number of polymer chains	1
Total formula weight	2397.64
Authors	Cifuentes, G.,Patarroyo, M.E.,Urquiza, M.,Ramirez, L.E.,Reyes, C.,Rodriguez, R. (deposition date: 2014-09-04, release date: 2014-11-12, Last modification date: 2024-05-15)
Primary citation	Cifuentes, G.,Patarroyo, M.E.,Urquiza, M.,Ramirez, L.E.,Reyes, C.,Rodriguez, R. Distorting malaria peptide backbone structure to enable fitting into MHC class II molecules renders modified peptides immunogenic and protective. J.Med.Chem., 46:2250-2253, 2003 Cited by PubMed Abstract: The conserved, nonantigenic, nonimmunogenic malaria Merozoite Surface Protein-2 peptide 1, having high affinity for red blood cells, was rendered immunogenic and protective in Aotus monkeys by specifically changing some critical residues. The NMR structure revealed a switch from classical type III' into distorted III' and III beta turns in the protective peptides. These changes may lead to a better fit into the Aotus MHC class II human HLA-DRbeta1 12 molecule equivalent, thus activating the immune system. PubMed: 12747797 DOI: 10.1021/jm020440w PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation