2MSC

NMR data-driven model of GTPase KRas-GDP tethered to a lipid-bilayer nanodisc

Summary for 2MSC

• Entry DOI: 10.2210/pdb2msc/pdb
• Related: 1AV1 2M4A 2M4B 2MSD 2MSE 3GFT 4DSN
• NMR Information: BMRB: 25114
• Descriptor: Apolipoprotein A-I, GTPase KRas, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... (6 entities in total)
• Functional Keywords: k-ras, nanodisc, pre, docking, lipid binding protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 131180.78

Authors

Mazhab-Jafari, M.,Stathopoulos, P.,Marshall, C.,Ikura, M. (deposition date: 2014-07-29, release date: 2015-06-03, Last modification date: 2024-05-01)

• Primary citation: Mazhab-Jafari, M.T.,Marshall, C.B.,Smith, M.J.,Gasmi-Seabrook, G.M.,Stathopulos, P.B.,Inagaki, F.,Kay, L.E.,Neel, B.G.,Ikura, M.; Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site.; Proc.Natl.Acad.Sci.USA, 112:6625-6630, 2015; PubMed: 25941399; DOI: 10.1073/pnas.1419895112

Experimental method

SOLUTION NMR