2MQU
Spatial structure of Hm-3, a membrane-active spider toxin affecting sodium channels
Summary for 2MQU
Entry DOI | 10.2210/pdb2mqu/pdb |
NMR Information | BMRB: 25050 |
Descriptor | Neurotoxin Hm-3 (1 entity in total) |
Functional Keywords | spider toxins, voltage-gated sodium channels, gating modifiers, inhibitor cystine knot, ick, channel activation, toxin |
Biological source | Heriaeus melloteei (Crab spider) |
Total number of polymer chains | 1 |
Total formula weight | 3919.71 |
Authors | Myshkin, M.Y.,Shenkarev, Z.O.,Paramonov, A.S.,Berkut, A.A.,Grishin, E.V.,Vassilevski, A.A. (deposition date: 2014-06-27, release date: 2014-11-05, Last modification date: 2023-06-14) |
Primary citation | Berkut, A.A.,Peigneur, S.,Myshkin, M.Y.,Paramonov, A.S.,Lyukmanova, E.N.,Arseniev, A.S.,Grishin, E.V.,Tytgat, J.,Shenkarev, Z.O.,Vassilevski, A.A. Structure of membrane-active toxin from crab spider Heriaeus melloteei suggests parallel evolution of sodium channel gating modifiers in Araneomorphae and Mygalomorphae. J. Biol. Chem., 290:492-504, 2015 Cited by PubMed: 25352595DOI: 10.1074/jbc.M114.595678 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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