2MPF

Solution structure human HCN2 CNBD in the cAMP-unbound state

Summary for 2MPF

Entry DOI	10.2210/pdb2mpf/pdb
NMR Information	BMRB: 19977
Descriptor	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (1 entity in total)
Functional Keywords	hcn channels, transport protein
Biological source	Homo sapiens (human)
Cellular location	Cell membrane ; Multi-pass membrane protein : Q9UL51
Total number of polymer chains	1
Total formula weight	17987.89
Authors	Saponaro, A.,Pauleta, S.R.,Cantini, F.,Matzapetakis, M.,Hammann, C.,Banci, L.,Thiel, G.,Santoro, B.,Moroni, A. (deposition date: 2014-05-16, release date: 2014-09-03, Last modification date: 2023-06-14)
Primary citation	Saponaro, A.,Pauleta, S.R.,Cantini, F.,Matzapetakis, M.,Hammann, C.,Donadoni, C.,Hu, L.,Thiel, G.,Banci, L.,Santoro, B.,Moroni, A. Structural basis for the mutual antagonism of cAMP and TRIP8b in regulating HCN channel function. Proc.Natl.Acad.Sci.USA, 111:14577-14582, 2014 Cited by PubMed: 25197093 DOI: 10.1073/pnas.1410389111 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation