2MMW
LASSO PEPTIDE BASED INTEGRIN INHIBITOR: MICROCIN J25 VARIANT WITH RGD SUBSTITUTION of GLY12-ILE13-GLY14
Summary for 2MMW
Entry DOI | 10.2210/pdb2mmw/pdb |
NMR Information | BMRB: 21000 |
Descriptor | Microcin J25 (1 entity in total) |
Functional Keywords | lasso peptide, microcin j25, epitope grafting, peptide scaffold, integrin inhibitor, angiogenesis, antimicrobial protein, cell adhesion inhibitor, antibiotic |
Biological source | Escherichia coli |
Cellular location | Secreted: Q9X2V7 |
Total number of polymer chains | 1 |
Total formula weight | 2228.42 |
Authors | Knappe, T.A.,Linne, U.,Xie, X.,Marahiel, M.A. (deposition date: 2014-03-20, release date: 2014-05-14) |
Primary citation | Knappe, T.A.,Manzenrieder, F.,Mas-Moruno, C.,Linne, U.,Sasse, F.,Kessler, H.,Xie, X.,Marahiel, M.A. Introducing lasso peptides as molecular scaffolds for drug design: engineering of an integrin antagonist. Angew.Chem.Int.Ed.Engl., 50:8714-8717, 2011 Cited by PubMed: 21812076DOI: 10.1002/anie.201102190 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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