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2MMW

LASSO PEPTIDE BASED INTEGRIN INHIBITOR: MICROCIN J25 VARIANT WITH RGD SUBSTITUTION of GLY12-ILE13-GLY14

Summary for 2MMW
Entry DOI10.2210/pdb2mmw/pdb
NMR InformationBMRB: 21000
DescriptorMicrocin J25 (1 entity in total)
Functional Keywordslasso peptide, microcin j25, epitope grafting, peptide scaffold, integrin inhibitor, angiogenesis, antimicrobial protein, cell adhesion inhibitor, antibiotic
Biological sourceEscherichia coli
Cellular locationSecreted: Q9X2V7
Total number of polymer chains1
Total formula weight2228.42
Authors
Knappe, T.A.,Linne, U.,Xie, X.,Marahiel, M.A. (deposition date: 2014-03-20, release date: 2014-05-14)
Primary citationKnappe, T.A.,Manzenrieder, F.,Mas-Moruno, C.,Linne, U.,Sasse, F.,Kessler, H.,Xie, X.,Marahiel, M.A.
Introducing lasso peptides as molecular scaffolds for drug design: engineering of an integrin antagonist.
Angew.Chem.Int.Ed.Engl., 50:8714-8717, 2011
Cited by
PubMed: 21812076
DOI: 10.1002/anie.201102190
PDB entries with the same primary citation
Experimental method
SOLUTION NMR
Structure validation

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