2MLI

NMR structure of B25-(alpha, beta)-dehydro-phenylalanine insulin

Summary for 2MLI
NMR InformationBMRB: 19822
DescriptorInsulin (2 entities in total)
Functional Keywordsinsulin analog, hormone
Biological sourceHomo sapiens (human)
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Cellular locationSecreted: P01308 P01308
Total number of polymer chains2
Total formula weight5792.58
Authors
Yang, Y.,Weiss, M. (deposition date: 2014-02-27, release date: 2014-08-20, Last modification date: 2014-09-03)
Primary citationCarroll, J.M.,Chan, S.J.,Chauhan, V.S.,Ismail-Beigi, F.,Lawrence, M.C.,Menting, J.G.,Milewski, W.,Pandyarajan, V.,Phillips, N.B.,Roberts, C.T.,Smith, B.J.,Steiner, D.F.,Strokes, N.,Wan, Z.L.,Ward, C.W.,Weiss, M.A.,Whittaker, J.,Whittaker, L.J.,Wickramasinghe, N.P.,Yadav, S.P.,Yang, Y.
Protective hinge in insulin opens to enable its receptor engagement.
Proc.Natl.Acad.Sci.USA, 111:E3395-E3404, 2014
PubMed: 25092300
DOI: 110.1073/pnas.1412897111
PDB entries with the same primary citation
Experimental method
SOLUTION NMR
Structure validation
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PDB entries from 2021-06-23