2MJV

Solution structures of second bromodomain of Brd4 with di-acetylated Twist peptide

Summary for 2MJV

• Entry DOI: 10.2210/pdb2mjv/pdb
• NMR Information: BMRB: 19738
• Descriptor: Twist-related protein 1, Bromodomain-containing protein 4 (2 entities in total)
• Functional Keywords: tumorigenesis, transcription
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: Q15672 O60885
• Total number of polymer chains: 2
• Total formula weight: 16142.52

Authors

Zeng, L.,Zhou, M. (deposition date: 2014-01-16, release date: 2014-03-19, Last modification date: 2023-11-15)

• Primary citation: Shi, J.,Wang, Y.,Zeng, L.,Wu, Y.,Deng, J.,Zhang, Q.,Lin, Y.,Li, J.,Kang, T.,Tao, M.,Rusinova, E.,Zhang, G.,Wang, C.,Zhu, H.,Yao, J.,Zeng, Y.X.,Evers, B.M.,Zhou, M.M.,Zhou, B.P.; Disrupting the Interaction of BRD4 with Diacetylated Twist Suppresses Tumorigenesis in Basal-like Breast Cancer.; Cancer Cell, 25:210-225, 2014; PubMed: 24525235; DOI: 10.1016/j.ccr.2014.01.028

Experimental method

SOLUTION NMR