2MAK

Solution structure of the STIM1 CC1-CC2 homodimer in complex with two Orai1 C-terminal domains.

Summary for 2MAK

• Entry DOI: 10.2210/pdb2mak/pdb
• Related: 2maj
• NMR Information: BMRB: 19363
• Descriptor: Stromal interaction molecule 1, Calcium release-activated calcium channel protein 1 (2 entities in total)
• Functional Keywords: stim1, orai1, coiled-coil, orai1 c-terminal domain, transport protein, signaling protein-transport protein complex, signaling protein/transport protein
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane; Single-pass type I membrane protein: Q13586; Cell membrane; Multi-pass membrane protein: Q96D31
• Total number of polymer chains: 4
• Total formula weight: 24715.59

Authors

Stathopulos, P.B.,Ikura, M. (deposition date: 2013-07-12, release date: 2014-01-15)

• Primary citation: Stathopulos, P.B.,Schindl, R.,Fahrner, M.,Zheng, L.,Gasmi-Seabrook, G.M.,Muik, M.,Romanin, C.,Ikura, M.; STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry.; Nat Commun, 4:2963-2963, 2013; PubMed: 24351972; DOI: 10.1038/ncomms3963

Experimental method

SOLUTION NMR