2MAK

Solution structure of the STIM1 CC1-CC2 homodimer in complex with two Orai1 C-terminal domains.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Stromal interaction molecule 1	polymer	82	9703.0	2	UniProt (Q13586) Pfam (PF16533) In PDB	Homo sapiens (human)
2	B, D	Calcium release-activated calcium channel protein 1	polymer	23	2654.8	2	UniProt (Q96D31) In PDB	Homo sapiens (human)	Protein orai-1, Transmembrane protein 142A

Sequence modifications

A, C: 312 - 387 (UniProt: Q13586)

PDB	External Database	Details
Gly -5	-	expression tag
Ser -4	-	expression tag
His -3	-	expression tag
Met -2	-	expression tag
Ala -1	-	expression tag
Ser 0	-	expression tag

B, D: 272 - 292 (UniProt: Q96D31)

PDB	External Database	Details
Gly -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	24715.6
All*	Total formula weight	24715.6

*Water molecules are not included.