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2M86

Solution structure of Hdm2 with engineered cyclotide

Summary for 2M86
Entry DOI10.2210/pdb2m86/pdb
NMR InformationBMRB: 19230
DescriptorMCo-PMI, E3 ubiquitin-protein ligase Mdm2 (2 entities in total)
Functional Keywordshdm2 oncoprotein, mcoti-i cyclotide, p53 tumor suppressor, protein binding-signaling protein complex, protein binding/signaling protein
Biological sourcesynthetic construct
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Cellular locationNucleus, nucleoplasm: 2M86
Total number of polymer chains2
Total formula weight19997.72
Authors
Majumder, S.,Ji, Y.,Millard, M.,Borra, R.,Bi, T.,Elnagar, A.Y.,Neamati, N.,Camarero, J.A. (deposition date: 2013-05-07, release date: 2013-07-31, Last modification date: 2023-06-14)
Primary citationJi, Y.,Majumder, S.,Millard, M.,Borra, R.,Bi, T.,Elnagar, A.Y.,Neamati, N.,Shekhtman, A.,Camarero, J.A.
In Vivo Activation of the p53 Tumor Suppressor Pathway by an Engineered Cyclotide.
J.Am.Chem.Soc., 135:11623-11633, 2013
Cited by
PubMed: 23848581
DOI: 10.1021/ja405108p
PDB entries with the same primary citation
Experimental method
SOLUTION NMR
Structure validation

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