2M59

Spatial structure of dimeric VEGFR2 membrane domain in DPC micelles

Summary for 2M59

• Entry DOI: 10.2210/pdb2m59/pdb
• NMR Information: BMRB: 19041
• Descriptor: Vascular endothelial growth factor receptor 2 (1 entity in total)
• Functional Keywords: vegfr2, receptor tyrosine kinase, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cell junction . Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted . Isoform 3: Secreted: P35968
• Total number of polymer chains: 2
• Total formula weight: 8262.13

Authors

Mineev, K.S.,Arseniev, A.S.,Shulepko, M.A.,Lyukmanova, E.N. (deposition date: 2013-02-19, release date: 2014-03-12, Last modification date: 2023-06-14)

• Primary citation: Manni, S.,Mineev, K.S.,Usmanova, D.,Lyukmanova, E.N.,Shulepko, M.A.,Kirpichnikov, M.P.,Winter, J.,Matkovic, M.,Deupi, X.,Arseniev, A.S.,Ballmer-Hofer, K.; Structural and functional characterization of alternative transmembrane domain conformations in VEGF receptor 2 activation.; Structure, 22:1077-1089, 2014; PubMed: 24980797; DOI: 10.1016/j.str.2014.05.010

Experimental method

SOLUTION NMR