2M20

EGFR transmembrane - juxtamembrane (TM-JM) segment in bicelles: MD guided NMR refined structure.

Summary for 2M20

• Entry DOI: 10.2210/pdb2m20/pdb
• NMR Information: BMRB: 18888
• Descriptor: Epidermal growth factor receptor (1 entity in total)
• Functional Keywords: transmembrane, cell signaling, juxtamembrane, signaling protein
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
• Total number of polymer chains: 2
• Total formula weight: 13558.50

Authors

Endres, N.F.,Das, R.,Smith, A.,Arkhipov, A.,Kovacs, E.,Huang, Y.,Pelton, J.G.,Shan, Y.,Shaw, D.E.,Wemmer, D.E.,Groves, J.T.,Kuriyan, J. (deposition date: 2012-12-11, release date: 2013-02-20, Last modification date: 2024-05-01)

• Primary citation: Endres, N.F.,Das, R.,Smith, A.W.,Arkhipov, A.,Kovacs, E.,Huang, Y.,Pelton, J.G.,Shan, Y.,Shaw, D.E.,Wemmer, D.E.,Groves, J.T.,Kuriyan, J.; Conformational Coupling across the Plasma Membrane in Activation of the EGF Receptor.; Cell(Cambridge,Mass.), 152:543-556, 2013; PubMed: 23374349; DOI: 10.1016/j.cell.2012.12.032

Experimental method

SOLUTION NMR