2LF1
Solution structure of L. casei dihydrofolate reductase complexed with NADPH, 30 structures
Summary for 2LF1
Entry DOI | 10.2210/pdb2lf1/pdb |
Related | 1LUD 2HM9 2L28 |
NMR Information | BMRB: 17311 |
Descriptor | Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (2 entities in total) |
Functional Keywords | oxidoreductase, dhfr, positive cooperativity, protein-ligand interactions |
Biological source | Lactobacillus casei |
Total number of polymer chains | 1 |
Total formula weight | 19077.01 |
Authors | Polshakov, V.,Feeney, J.,Birdsall, B.,Kovalevskaya, N. (deposition date: 2011-06-28, release date: 2011-12-21, Last modification date: 2024-05-01) |
Primary citation | Feeney, J.,Birdsall, B.,Kovalevskaya, N.V.,Smurnyy, Y.D.,Navarro Peran, E.M.,Polshakov, V.I. NMR structures of apo L. casei dihydrofolate reductase and its complexes with trimethoprim and NADPH: contributions to positive cooperative binding from ligand-induced refolding, conformational changes, and interligand hydrophobic interactions Biochemistry, 50:3609-3620, 2011 Cited by PubMed: 21410224PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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