2K7W

BAX Activation is Initiated at a Novel Interaction Site

Summary for 2K7W

• Entry DOI: 10.2210/pdb2k7w/pdb
• Related: 1F16
• Descriptor: Apoptosis regulator BAX, Bcl-2-like protein 11 (2 entities in total)
• Functional Keywords: bax, bim, bh3, bcl-2, apoptosis
• Biological source: Homo sapiens (human)
• Cellular location: Isoform Alpha: Mitochondrion membrane; Single-pass membrane protein. Isoform Beta: Cytoplasm. Isoform Gamma: Cytoplasm. Isoform Delta: Cytoplasm (Potential): Q07812; Endomembrane system; Peripheral membrane protein (By similarity). Isoform BimEL: Mitochondrion. Isoform BimL: Mitochondrion. Isoform BimS: Mitochondrion. Isoform Bim-alpha1: Mitochondrion: O43521
• Total number of polymer chains: 2
• Total formula weight: 23664.07

Authors

Gavathiotis, E.,Suzuki, M.,Davis, M.L.,Pitter, K.,Bird, G.H.,Katz, S.G.,Tu, H.C.,Kim, H.,Cheng, E.H.,Tjandra, N.,Walensky, L.D. (deposition date: 2008-08-27, release date: 2008-10-21, Last modification date: 2022-03-16)

• Primary citation: Gavathiotis, E.,Suzuki, M.,Davis, M.L.,Pitter, K.,Bird, G.H.,Katz, S.G.,Tu, H.C.,Kim, H.,Cheng, E.H.,Tjandra, N.,Walensky, L.D.; BAX activation is initiated at a novel interaction site.; Nature, 455:1076-1081, 2008; PubMed: 18948948; DOI: 10.1038/nature07396

Experimental method

SOLUTION NMR