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2K7W

BAX Activation is Initiated at a Novel Interaction Site

Functional Information from GO Data
ChainGOidnamespacecontents
A0001541biological_processovarian follicle development
A0001764biological_processneuron migration
A0001776biological_processleukocyte homeostasis
A0001777biological_processT cell homeostatic proliferation
A0001782biological_processB cell homeostasis
A0001783biological_processB cell apoptotic process
A0001822biological_processkidney development
A0001836biological_processrelease of cytochrome c from mitochondria
A0001974biological_processblood vessel remodeling
A0002262biological_processmyeloid cell homeostasis
A0002352biological_processB cell negative selection
A0002358biological_processB cell homeostatic proliferation
A0002904biological_processpositive regulation of B cell apoptotic process
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005635cellular_componentnuclear envelope
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005741cellular_componentmitochondrial outer membrane
A0005757cellular_componentmitochondrial permeability transition pore complex
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005829cellular_componentcytosol
A0006687biological_processglycosphingolipid metabolic process
A0006808biological_processregulation of nitrogen utilization
A0006915biological_processapoptotic process
A0006974biological_processDNA damage response
A0007005biological_processmitochondrion organization
A0007281biological_processgerm cell development
A0007283biological_processspermatogenesis
A0007399biological_processnervous system development
A0007548biological_processsex differentiation
A0008053biological_processmitochondrial fusion
A0008283biological_processcell population proliferation
A0008285biological_processnegative regulation of cell population proliferation
A0008289molecular_functionlipid binding
A0008584biological_processmale gonad development
A0008625biological_processextrinsic apoptotic signaling pathway via death domain receptors
A0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
A0008637biological_processapoptotic mitochondrial changes
A0009566biological_processfertilization
A0009611biological_processresponse to wounding
A0009636biological_processresponse to toxic substance
A0009651biological_processresponse to salt stress
A0009791biological_processpost-embryonic development
A0010212biological_processresponse to ionizing radiation
A0010248biological_processestablishment or maintenance of transmembrane electrochemical gradient
A0010332biological_processresponse to gamma radiation
A0010524biological_processpositive regulation of calcium ion transport into cytosol
A0010917biological_processnegative regulation of mitochondrial membrane potential
A0015267molecular_functionchannel activity
A0016020cellular_componentmembrane
A0021854biological_processhypothalamus development
A0021987biological_processcerebral cortex development
A0030544molecular_functionHsp70 protein binding
A0031334biological_processpositive regulation of protein-containing complex assembly
A0031966cellular_componentmitochondrial membrane
A0032091biological_processnegative regulation of protein binding
A0032469biological_processendoplasmic reticulum calcium ion homeostasis
A0032471biological_processnegative regulation of endoplasmic reticulum calcium ion concentration
A0032976biological_processrelease of matrix enzymes from mitochondria
A0033599biological_processregulation of mammary gland epithelial cell proliferation
A0034620biological_processcellular response to unfolded protein
A0034644biological_processcellular response to UV
A0035108biological_processlimb morphogenesis
A0035234biological_processectopic germ cell programmed cell death
A0042475biological_processodontogenesis of dentin-containing tooth
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0042981biological_processregulation of apoptotic process
A0043065biological_processpositive regulation of apoptotic process
A0043523biological_processregulation of neuron apoptotic process
A0043524biological_processnegative regulation of neuron apoptotic process
A0043525biological_processpositive regulation of neuron apoptotic process
A0043653biological_processmitochondrial fragmentation involved in apoptotic process
A0045136biological_processdevelopment of secondary sexual characteristics
A0046666biological_processretinal cell programmed cell death
A0046930cellular_componentpore complex
A0046982molecular_functionprotein heterodimerization activity
A0048087biological_processpositive regulation of developmental pigmentation
A0048147biological_processnegative regulation of fibroblast proliferation
A0048515biological_processspermatid differentiation
A0048597biological_processpost-embryonic camera-type eye morphogenesis
A0048678biological_processresponse to axon injury
A0048872biological_processhomeostasis of number of cells
A0048873biological_processhomeostasis of number of cells within a tissue
A0050673biological_processepithelial cell proliferation
A0051087molecular_functionprotein-folding chaperone binding
A0051094biological_processpositive regulation of developmental process
A0051204biological_processprotein insertion into mitochondrial membrane
A0051209biological_processrelease of sequestered calcium ion into cytosol
A0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
A0051402biological_processneuron apoptotic process
A0051434molecular_functionBH3 domain binding
A0051649biological_processestablishment of localization in cell
A0051726biological_processregulation of cell cycle
A0051881biological_processregulation of mitochondrial membrane potential
A0060011biological_processSertoli cell proliferation
A0060041biological_processretina development in camera-type eye
A0060057biological_processapoptotic process involved in mammary gland involution
A0060058biological_processpositive regulation of apoptotic process involved in mammary gland involution
A0060068biological_processvagina development
A0060402biological_processcalcium ion transport into cytosol
A0070059biological_processintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
A0070062cellular_componentextracellular exosome
A0070242biological_processthymocyte apoptotic process
A0071944cellular_componentcell periphery
A0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
A0090200biological_processpositive regulation of release of cytochrome c from mitochondria
A0097049biological_processmotor neuron apoptotic process
A0097136cellular_componentBcl-2 family protein complex
A0097144cellular_componentBAX complex
A0097145cellular_componentBAK complex
A0097190biological_processapoptotic signaling pathway
A0097191biological_processextrinsic apoptotic signaling pathway
A0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
A0097193biological_processintrinsic apoptotic signaling pathway
A0097194biological_processexecution phase of apoptosis
A0097435biological_processsupramolecular fiber organization
A0098586biological_processcellular response to virus
A1902108biological_processregulation of mitochondrial membrane permeability involved in apoptotic process
A1902110biological_processpositive regulation of mitochondrial membrane permeability involved in apoptotic process
A1902262biological_processapoptotic process involved in blood vessel morphogenesis
A1902263biological_processapoptotic process involved in embryonic digit morphogenesis
A1902445biological_processregulation of mitochondrial membrane permeability involved in programmed necrotic cell death
A1902512biological_processpositive regulation of apoptotic DNA fragmentation
A1902531biological_processregulation of intracellular signal transduction
A1903896biological_processpositive regulation of IRE1-mediated unfolded protein response
A1904019biological_processepithelial cell apoptotic process
A1904037biological_processpositive regulation of epithelial cell apoptotic process
A1990117biological_processB cell receptor apoptotic signaling pathway
A2000243biological_processpositive regulation of reproductive process
A2000673biological_processpositive regulation of motor neuron apoptotic process
A2001233biological_processregulation of apoptotic signaling pathway
A2001234biological_processnegative regulation of apoptotic signaling pathway
A2001244biological_processpositive regulation of intrinsic apoptotic signaling pathway
Functional Information from PROSITE/UniProt
site_idPS01080
Number of Residues20
DetailsBH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. MFsDGnfNWGRVVALFyFAS
ChainResidueDetails
AMET99-SER118

site_idPS01258
Number of Residues12
DetailsBH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WIqdqGGWDgLL
ChainResidueDetails
ATRP151-LEU162

site_idPS01259
Number of Residues15
DetailsBH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. LsecLKrIGDELDSN
ChainResidueDetails
ALEU59-ASN73

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues20
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
ATHR172-GLY192

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N-acetylmethionine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:25944712
ChainResidueDetails
AMET1

site_idSWS_FT_FI3
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36361894
ChainResidueDetails
ALYS128
ALYS190

227111

PDB entries from 2024-11-06

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