2IPK
Crystal Structure of the MHC Class II Molecule HLA-DR1 in Complex with the Fluorogenic Peptide, AcPKXVKQNTLKLAT (X=3-[5-(dimethylamino)-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl]-L-alanine) and the Superantigen, SEC3 Variant 3B2
Summary for 2IPK
Entry DOI | 10.2210/pdb2ipk/pdb |
Related | 1DLH 1JWU |
Descriptor | HLA class II histocompatibility antigen, DR alpha chain, HLA class II histocompatibility antigen, DRB1-1 beta chain, HA related Fluorogenic Peptide, AcPKXVKQNTLKLAT (X=3-[5-(dimethylamino)-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl]-L-alanine), ... (5 entities in total) |
Functional Keywords | hla, dr1, mhc, major histocompatibility complex, fluorogenic probe, sec3, 4-(n, n-dimethylamino)phthalimidoalanyl, dapa, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Cell membrane; Single-pass type I membrane protein: P01903 P04229 Secreted: P0A0L3 |
Total number of polymer chains | 4 |
Total formula weight | 72848.96 |
Authors | Nguyen, T.T.,Stern, L.J. (deposition date: 2006-10-12, release date: 2007-03-13, Last modification date: 2023-08-30) |
Primary citation | Venkatraman, P.,Nguyen, T.T.,Sainlos, M.,Bilsel, O.,Chitta, S.,Imperiali, B.,Stern, L.J. Fluorogenic probes for monitoring peptide binding to class II MHC proteins in living cells. Nat.Chem.Biol., 3:222-228, 2007 Cited by PubMed: 17351628DOI: 10.1038/nchembio868 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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