2IPK
Crystal Structure of the MHC Class II Molecule HLA-DR1 in Complex with the Fluorogenic Peptide, AcPKXVKQNTLKLAT (X=3-[5-(dimethylamino)-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl]-L-alanine) and the Superantigen, SEC3 Variant 3B2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HLA class II histocompatibility antigen, DR alpha chain | polymer | 183 | 21287.1 | 1 | UniProt (P01903) Pfam (PF00993) Pfam (PF07654) | Homo sapiens (human) | MHC class II antigen DRA |
| 2 | B (B) | HLA class II histocompatibility antigen, DRB1-1 beta chain | polymer | 190 | 22080.7 | 1 | UniProt (P04229) Pfam (PF00969) Pfam (PF07654) UniProt (by SIFTS) (P01911) | Homo sapiens (human) | MHC class I antigen DRB1*1, DR-1, DR1 |
| 3 | C (C) | HA related Fluorogenic Peptide, AcPKXVKQNTLKLAT (X=3-[5-(dimethylamino)-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl]-L-alanine) | polymer | 14 | 1628.9 | 1 | UniProt (by SIFTS) (A8CDU0) | Influenza A virus | |
| 4 | D (D) | Enterotoxin type C-3 | polymer | 240 | 27852.3 | 1 | UniProt (P0A0L3) Pfam (PF01123) Pfam (PF02876) UniProt (by SIFTS) (P0A0L5) | Staphylococcus aureus subsp. aureus Mu50 | SEC3 |
| 5 | E, F, G, H (A, B, C, D) | water | water | 18.0 | 419 | Chemie (HOH) |
Sequence modifications
A: 1 - 182 (UniProt: P01903)
D: 1 - 239 (UniProt: P0A0L3)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | cloning artifact |
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | cloning artifact |
| Ser 43 | Lys 70 | engineered mutation |
| Phe 45 | Leu 72 | engineered mutation |
| Lys 46 | Ala 73 | engineered mutation |
| Trp 47 | His 74 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 72849.0 | |
| All* | Total formula weight | 72849.0 |
