2INQ
Neutron Crystal Structure of Escherichia coli Dihydrofolate Reductase Bound to the Anti-cancer drug, Methotrexate
Summary for 2INQ
Entry DOI | 10.2210/pdb2inq/pdb |
Descriptor | Dihydrofolate reductase, N-(4-{[(2,4-DIAMINOPTERIDIN-1-IUM-6-YL)METHYL](METHYL)AMINO}BENZOYL)-L-GLUTAMIC ACID (3 entities in total) |
Functional Keywords | neutron structure; deuterium exchange; pseudo-rossman fold; nucleotide binding domain; chemotherapy, oxidoreductase |
Biological source | Escherichia coli K12 |
Total number of polymer chains | 2 |
Total formula weight | 36951.55 |
Authors | Bennett, B.C.,Langan, P.A.,Coates, L.,Schoenborn, B.,Dealwis, C.G. (deposition date: 2006-10-08, release date: 2007-02-06, Last modification date: 2023-08-30) |
Primary citation | Bennett, B.C.,Langan, P.A.,Coates, L.,Mustyakimov, M.,Schoenborn, B.,Howell, E.E.,Dealwis, C.G. Neutron diffraction studies of Escherichia coli dihydrofolate reductase complexed with methotrexate. Proc.Natl.Acad.Sci.Usa, 103:18493-18498, 2006 Cited by PubMed: 17130456DOI: 10.1073/pnas.0604977103 PDB entries with the same primary citation |
Experimental method | NEUTRON DIFFRACTION (2.2 Å) |
Structure validation
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