2IAJ

Crystal Structure of K103N/Y181C Mutant HIV-1 Reverse Transcriptase (RT) in Complex with ATP

Summary for 2IAJ

Entry DOI	10.2210/pdb2iaj/pdb
Related	1BQM 1DLO 1SV5 1UWB 2HMI 2IC3
Descriptor	Reverse transcriptase/ribonuclease H (p66 RT), Reverse transcriptase/ribonuclease H; p51 RT, MANGANESE (II) ION, ... (7 entities in total)
Functional Keywords	rt, nnrti, nonnucleoside inhibitor, drug resistance, dna polymerization, hiv, aids, drug design, transferase
Biological source	Human immunodeficiency virus type 1 BH10 More
Cellular location	Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366
Total number of polymer chains	2
Total formula weight	117275.59
Authors	Das, K.,Arnold, E. (deposition date: 2006-09-08, release date: 2006-12-19, Last modification date: 2023-08-30)
Primary citation	Das, K.,Sarafianos, S.G.,Clark, A.D.,Boyer, P.L.,Hughes, S.H.,Arnold, E. Crystal Structures of Clinically Relevant Lys103Asn/Tyr181Cys Double Mutant HIV-1 Reverse Transcriptase in Complexes with ATP and Non-nucleoside Inhibitor HBY 097. J.Mol.Biol., 365:77-89, 2007 Cited by PubMed: 17056061 DOI: 10.1016/j.jmb.2006.08.097 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation