2I5J
Crystal structure of HIV-1 reverse transcriptase (RT) in complex with DHBNH, an RNASE H inhibitor
Summary for 2I5J
Entry DOI | 10.2210/pdb2i5j/pdb |
Related PRD ID | PRD_900003 |
Descriptor | Reverse transcriptase/ribonuclease H P66 subunit, Reverse transcriptase/ribonuclease H P51 subunit, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, ... (7 entities in total) |
Functional Keywords | aids, hiv, reverse transcriptase, rt, rnase h inhibitor, rnhi, structure-based drug design, protein-inhibitor complex, drug resistance, transferase |
Biological source | Human immunodeficiency virus 1 More |
Total number of polymer chains | 2 |
Total formula weight | 115398.26 |
Authors | Himmel, D.M.,Sarafianos, S.G.,Knight, J.L.,Levy, R.M.,Arnold, E. (deposition date: 2006-08-24, release date: 2006-12-05, Last modification date: 2023-08-30) |
Primary citation | Himmel, D.M.,Sarafianos, S.G.,Dharmasena, S.,Hossain, M.M.,McCoy-Simandle, K.,Ilina, T.,Clark, A.D.,Knight, J.L.,Julias, J.G.,Clark, P.K.,Krogh-Jespersen, K.,Levy, R.M.,Hughes, S.H.,Parniak, M.A.,Arnold, E. HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site. Acs Chem.Biol., 1:702-712, 2006 Cited by PubMed: 17184135DOI: 10.1021/cb600303y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.15 Å) |
Structure validation
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