2I5J
Crystal structure of HIV-1 reverse transcriptase (RT) in complex with DHBNH, an RNASE H inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Reverse transcriptase/ribonuclease H P66 subunit | polymer | 552 | 63659.9 | 1 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) | Human immunodeficiency virus 1 | |
| 2 | B (B) | Reverse transcriptase/ribonuclease H P51 subunit | polymer | 429 | 50152.6 | 1 | UniProt (P03366) Pfam (PF00078) UniProt (by SIFTS) (Q8UM83) | Human immunodeficiency virus 1 | |
| 3 | C, D (C, D) | beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose | branched | 342.3 | 2 | In PDB BIRD (PRD_900003) | sucrose | ||
| 4 | E, F, I (A, B) | alpha-D-glucopyranose | non-polymer | 180.2 | 3 | Chemie (GLC) | |||
| 5 | G (A) | (E)-3,4-DIHYDROXY-N'-[(2-METHOXYNAPHTHALEN-1-YL)METHYLENE]BENZOHYDRAZIDE | non-polymer | 336.3 | 1 | Chemie (K05) | |||
| 6 | H (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 7 | J, K (A, B) | water | water | 18.0 | 36 | Chemie (HOH) |
Sequence modifications
A: 1 - 552 (UniProt: P03366)
B: 1 - 429 (UniProt: P03366)
| PDB | External Database | Details |
|---|---|---|
| Ser 280 | Cys 878 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 280 | Cys 878 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 113812.6 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 684.6 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 901.1 | |
| All* | Total formula weight | 115398.3 |
