2HUW
X-ray crystal structure of the Grb2 SH2 domain complexed to a constrained and cyclopropane-derived ligand
Summary for 2HUW
Entry DOI | 10.2210/pdb2huw/pdb |
Descriptor | Growth factor receptor-bound protein 2, N-({(1R,2R,3S)-2-(methylcarbamoyl)-3-[4-(phosphonooxy)phenyl]cyclopropyl}carbonyl)-L-valyl-L-aspartamide, PHOSPHATE ION, ... (4 entities in total) |
Functional Keywords | cylcopropane, contrained, grb2, sh2, preorganization, hormone-growth factor complex, hormone/growth factor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus : P62993 |
Total number of polymer chains | 2 |
Total formula weight | 28524.83 |
Authors | Benfield, A.P.,Martin, S.F. (deposition date: 2006-07-27, release date: 2006-08-15, Last modification date: 2024-02-14) |
Primary citation | Benfield, A.P.,Teresk, M.G.,Plake, H.R.,Delorbe, J.E.,Millspaugh, L.E.,Martin, S.F. Ligand Preorganization May Be Accompanied by Entropic Penalties in Protein-Ligand Interactions. Angew.Chem.Int.Ed.Engl., 45:6830-6835, 2006 Cited by PubMed: 17001728DOI: 10.1002/anie.200600844 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
Download full validation report