2HIZ

Crystal Structure of human beta-secretase (BACE) in the presence of an inhibitor

Summary for 2HIZ

Entry DOI	10.2210/pdb2hiz/pdb
Descriptor	Beta-secretase 1, PHOSPHATE ION, BENZYL [(1S)-2-({(1S,2R)-1-BENZYL-2-HYDROXY-3-[(3-METHOXYBENZYL)AMINO]PROPYL}AMINO)-2-OXO-1-{[(1-PROPYLBUTYL)SULFONYL]METHYL}ETHYL]CARBAMATE, ... (4 entities in total)
Functional Keywords	protein-inhibitor complex, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein: P56817
Total number of polymer chains	3
Total formula weight	153040.24
Authors	Benson, T.E.,Prince, D.B.,Tomasselli, A.G.,Emmons, T.L.,Paddock, D.J. (deposition date: 2006-06-29, release date: 2007-01-23, Last modification date: 2017-10-18)
Primary citation	Freskos, J.N.,Fobian, Y.M.,Benson, T.E.,Bienkowski, M.J.,Brown, D.L.,Emmons, T.L.,Heintz, R.,Laborde, A.,McDonald, J.J.,Mischke, B.V.,Molyneaux, J.M.,Moon, J.B.,Mullins, P.B.,Bryan Prince, D.,Paddock, D.J.,Tomasselli, A.G.,Winterrowd, G. Design of potent inhibitors of human beta-secretase. Part 1. Bioorg.Med.Chem.Lett., 17:73-77, 2007 Cited by PubMed: 17046251 DOI: 10.1016/j.bmcl.2006.09.092 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation