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2HIZ

Crystal Structure of human beta-secretase (BACE) in the presence of an inhibitor

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C
(A, B, C)
Beta-secretase 1polymer45550250.63UniProt (P56817)
Pfam (PF00026)
Homo sapiens (human)Beta-site APP cleaving enzyme 1, Beta-site amyloid precursor protein cleaving enzyme 1, Aspartyl protease 2, Asp 2, ASP2, Membrane-associated aspartic protease 2, Memapsin-2
2D, E, H
(A, C)
PHOSPHATE IONnon-polymer95.03Chemie (PO4)
3F, G, I
(A, B, C)
BENZYL [(1S)-2-({(1S,2R)-1-BENZYL-2-HYDROXY-3-[(3-METHOXYBENZYL)AMINO]PROPYL}AMINO)-2-OXO-1-{[(1-PROPYLBUTYL)SULFONYL]METHYL}ETHYL]CARBAMATEnon-polymer667.93Chemie (LIJ)
4J, K, L
(A, B, C)
waterwater18.0230Chemie (HOH)
Sequence modifications
A, B, C: 16 - 392 (UniProt: P56817)
PDBExternal DatabaseDetails
Met 1-cloning artifact
Ala 2-cloning artifact
Ser 3-cloning artifact
Met 4-cloning artifact
Thr 5-cloning artifact
Gly 6-cloning artifact
Gly 7-cloning artifact
Gln 8-cloning artifact
Gln 9-cloning artifact
Met 10-cloning artifact
Gly 11-cloning artifact
Arg 12-cloning artifact
Gly 13-cloning artifact
Ser 14-cloning artifact
Met 15-cloning artifact
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains3
Total formula weight150751.8
Non-Polymers*Number of molecules6
Total formula weight2288.5
All*Total formula weight153040.2
*Water molecules are not included.

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PDB entries from 2025-10-15

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