2HIZ
Crystal Structure of human beta-secretase (BACE) in the presence of an inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C | Beta-secretase 1 | polymer | 455 | 50250.6 | 3 | UniProt (P56817) Pfam (PF00026) In PDB | Homo sapiens (human) | Beta-site APP cleaving enzyme 1, Beta-site amyloid precursor protein cleaving enzyme 1, Aspartyl protease 2, Asp 2, ASP2, Membrane-associated aspartic protease 2, Memapsin-2 |
2 | A, C | PHOSPHATE ION | non-polymer | 95.0 | 3 | Chemie (PO4) | |||
3 | A, B, C | BENZYL [(1S)-2-({(1S,2R)-1-BENZYL-2-HYDROXY-3-[(3-METHOXYBENZYL)AMINO]PROPYL}AMINO)-2-OXO-1-{[(1-PROPYLBUTYL)SULFONYL]METHYL}ETHYL]CARBAMATE | non-polymer | 667.9 | 3 | Chemie (LIJ) | |||
4 | water | water | 18.0 | 230 | Chemie (HOH) |
Sequence modifications
A, B, C: 16 - 392 (UniProt: P56817)
PDB | External Database | Details |
---|---|---|
Met 1 | - | CLONING ARTIFACT |
Ala 2 | - | CLONING ARTIFACT |
Ser 3 | - | CLONING ARTIFACT |
Met 4 | - | CLONING ARTIFACT |
Thr 5 | - | CLONING ARTIFACT |
Gly 6 | - | CLONING ARTIFACT |
Gly 7 | - | CLONING ARTIFACT |
Gln 8 | - | CLONING ARTIFACT |
Gln 9 | - | CLONING ARTIFACT |
Met 10 | - | CLONING ARTIFACT |
Gly 11 | - | CLONING ARTIFACT |
Arg 12 | - | CLONING ARTIFACT |
Gly 13 | - | CLONING ARTIFACT |
Ser 14 | - | CLONING ARTIFACT |
Met 15 | - | CLONING ARTIFACT |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 150751.8 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 2288.5 | |
All* | Total formula weight | 153040.2 |